From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickes...
Rational drug design: How far have we come?
Study suggests PD-1 inhibitors against aggressive pediatric brain cancer subtype
One type of immunotherapy removes a genetic blindfold that cancer uses to hide from the immune system. These “PD-1 inhibitors,” including drugs like pembrolizumab, nivolumab and atezolizum...
Scientists target glioma cancer stem cells, which could improve patient survival
Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers. Despite surgery, radiation and chemotherapy, these tumors virtuall...
Study suggests way to attack deadly, untreatable nerve tumors
Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse mo...
Combination chemotherapy may significantly improve treatment for deadly brain tumor
A diagnosis of the brain cancer glioblastoma carries a dismal prognosis, with most patients dying within five years. Now a team led by Massachusetts General Hospital (MGH) investigators has found that...
Zika virus could help combat brain cancer
Zika virus, feared for causing microcephaly in babies whose mothers were infected during pregnancy by attacking the cells that will give rise to the fetus’s cerebral cortex, could be an alternat...
Largest study of its kind finds alcohol use biggest risk factor for dementia
Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. This according to a nationwide observational study, publi...
Scientists block the siren call of two aggressive cancers
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive. Scientis...